Ash severity than placebo.42 Ziaei et al. studied the effects of vitamin E on menopausal hot flashes.43 They reported that vitamin E and Caspase 5 Purity & Documentation placebo each lowered hot flashes, but there was a significant distinction in between them in terms of minimizing hot flashseverity score and hot flash frequency. These benefits were constant together with the results from the present study. Loprinzi et al. studied the effects of venlafaxine with distinctive dosages through 4 weeks on 221 ladies with breast cancer.44 They reported a reduction in hot flash severity scores of 31 to 61 versus 27 in placebo, in addition to a reduction in hot flash frequency of 30 to 58 versus 19 in placebo. The effects of Scitalopram compared with placebo in treating hot flash in 205 ladies was studied by Freeman et al.45 They found that Scitalopram was extra powerful in minimizing hot flash severity soon after eight weeks in comparison with placebo. Stearns et al. Studied the effects of paroxetine in the remedy of hot flash.46 A 62.two lower was observed in hot flash with paroxetine with the dosage of 12.5 mg as well as a 64.four reduce with all the dosage of 25 mg right after six weeks of therapy, and also a 37.8 reduce by placebo. The mean day-to-day hot flash frequency using a dosage of 12.five mg decreased from 7.1 to 3.eight, using a dosage of 25 mg it decreased from 6.four to three.3, and in placebo from six.6 to 4.8. An additional study around the effects of venlafaxine on hot flash of girls triggered by breast cancer was performed by Carpenter et al.47 This study indicated that venlafaxine was additional productive than placebo. Gordon et al. also reported that sertraline was more effective in reducing hot flashes in 102 women with menopause in comparison with placebo.48The benefits of those studies are similar to the present study which is due to their comparable mechanism. Even so, the outcomes from the study by Grady et al. indicated that sertraline was not helpful around the frequency and severity of perimenopausal and postmenopausal hot flashes.49 SuvantoLuukkonen et al. cond-ucted a randomized clinical trial throughout 9 months around the effects of citalopram and fluoxetine on hot flashes in 150 menopausal females. They reported that there was no significant distinction between the groups with regards to hot flash frequency.50 Bouchard et al. studied the effects ofJournal of Caring Sciences, Jun 2013; two (2), 131-140|Copyright 2013 by Tabriz University of Health-related SciencesBani et al.desvenlafaxine on vasomotor symptoms, in 35 regions of Europe, 2 regions of South Africa, and one region of Mexico.51 In week 12 no substantial distinction was observed in the reduction of imply frequency of everyday hot flashes among the groups. Inside the present study folic acid had no side effects; consequently, it may be employed for lowering hot flashes and improving the women’s quality of life. Considering that you can find a limited quantity of research around the impact of folic acid on menopausal hot flash, further studies on this matter are advised.ConclusionThe outcomes on the present study indicated that folic acid and placebo were both efficient inside the improvement of hot flash. However, folic acid was more successful. Folic acid is actually a secure, cost-effective, and acceptable Cereblon Source medication for girls; therefore, it might be viewed as as an alternative approach for relieving menopausal hot flashes.Ethical issuesNone to become declared.Conflict of interestThe authors declare no conflict of interest in this study.AcknowledgmentsOur appreciation goes towards the analysis deputy of Tabriz University of Healthcare Sciences for the financial assistance,.