Product Name: CCRK (885CT27.1.1) Monoclonal Antibody
Applications: WB
Reactivity: Human
Conjugation: Unconjugated
Host: Mouse
Sourcr: Purified His-tagged CCRK protein was used to produced this monoclonal antibody.
Clonality: Monoclonal
CAS NO: 24219-97-4
Product: Balicatib
Isotype: IgG1
Concentration:
Purification: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage: Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Synonyms: P42; CCRK; CDCH; PNQALRE; Cyclin-dependent kinase 20; CDK-activating kinase p42; CAK-kinase p42; Cell cycle-related kinase; Cell division protein kinase 20; Cyclin-dependent protein kinase H; Cyclin-kinase-activating kinase p42; CDK20
Background: Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling (By similarity). Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue Thr-160.
PubMed ID:http://jpet.aspetjournals.org/content/305/2/733
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