Product Name: CCDC58 Polyclonal Antibody, Cy3 Conjugated
Applications: IF(IHC-P)
Reactivity: Human, Mouse, Rat
Conjugation: Cy3
Host: Rabbit
Sourcr: KLH conjugated synthetic peptide derived from human CCDC58
Clonality: Polyclonal
CAS NO: 156161-89-6
Product: LY310762
Isotype: IgG
Concentration: 1ug/ul
Purification: Purified by Protein A.
Storage: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Synonyms: CCD58_HUMAN; ccdc58; Coiled-coil domain-containing protein 58; FLJ33273; MGC36453; RGD1564582; A930007B11Rik; AI413631.
Background: The coiled-coil domain is a structural motif found in proteins that are involved in a diverse array of biological functions such as the regulation of gene expression, cell division, membrane fusion and drug extrusion and delivery. CCDC58 (coiled-coil domain containing 58) is a 144 amino acid protein that is encoded by a gene that maps to human chromosome 3q21.1. Chromosome 3 is made up of about 214 million bases encoding over 1,100 genes. Notably, there is a chemokine receptor gene cluster and a variety of human cancer related loci on chromosome 3. Particular regions of the chromosome 3 short arm are deleted in many types of cancer cells. Key tumor suppressing genes on chromosome 3 encode apoptosis mediator RASSF1, cell migration regulator HYAL1 and angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth Disease are a few of the numerous genetic diseases associated with chromosome 3.
PubMed ID:http://jpet.aspetjournals.org/content/301/3/915
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