Product Name: CCDC69 Polyclonal Antibody, Cy5.5 Conjugated
Applications: IF(IHC-P)
Reactivity: Human
Conjugation: Cy5.5
Host: Rabbit
Sourcr: KLH conjugated synthetic peptide derived from human CCDC69
Clonality: Polyclonal
CAS NO: 79660-72-3
Product: iCRT 14
Isotype: IgG
Concentration: 1ug/ul
Purification: Purified by Protein A.
Storage: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Synonyms: CCD69_HUMAN; ccdc69; Coiled coil domain containing 69; Coiled-coil domain-containing protein 69.
Background: The coiled-coil domain is a structural motif found in proteins that are involved in a diverse array of biological functions such as the regulation of gene expression, cell division, membrane fusion and drug extrusion and delivery. CCDC69 (Coiled-coil domain-containing protein 69) is a 296 amino acid protein that is encoded by a gene which maps to human chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome. Chromosome 5 is associated with Cockayne syndrome through the ERCC8 gene and familial adenomatous polyposis through the adenomatous polyposis coli (APC) tumor suppressor gene. Treacher Collins syndrome is also chromosome 5-associated and is caused by insertions or deletions within the TCOF1 gene. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome, while deletion of the q arm or of chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.
PubMed ID:http://jpet.aspetjournals.org/content/302/2/539
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