Product Name: CCDC98 Polyclonal Antibody, HRP Conjugated
Applications: WB, IHC-P
Reactivity: Human, Mouse, Rat
Conjugation: HRP
Host: Rabbit
Sourcr: KLH conjugated synthetic peptide derived from human CCDC98
Clonality: Polyclonal
CAS NO: 124-94-7
Product: Hoechst 33342 (trihydrochloride)
Isotype: IgG
Concentration: 1ug/ul
Purification: Purified by Protein A.
Storage: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% Gentamicin. Store at 4°C for 12 months.
Synonyms: ABRA1; CCDC98; BRCA1-A complex subunit Abraxas; Coiled-coil domain-containing protein 98; Protein FAM175A; FAM175A; UNQ496/PRO1013
Background: Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes Lys-63-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes Lys-63-linked ubiquitin on histones H2A and H2AX.
PubMed ID:http://jpet.aspetjournals.org/content/303/3/1029
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