Product Name: CD161 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated
Applications: IF(IHC-P)
Reactivity: Human
Conjugation: ALEXA FLUOR® 555
Host: Rabbit
Sourcr: KLH conjugated synthetic peptide derived from human CD161/NK11
Clonality: Polyclonal
CAS NO: 1395084-25-9
Product: Acetylcholine (chloride)
Isotype: IgG
Concentration: 1ug/ul
Purification: Purified by Protein A.
Storage: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Synonyms: NKR; CD161; CLEC5B; NKR-P1; NKRP1A; NKR-P1A; hNKR-P1A; Killer cell lectin-like receptor subfamily B member 1; C-type lectin domain family 5 member B; Natural killer cell surface protein P1A; KLRB1
Background: Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.
PubMed ID:http://jpet.aspetjournals.org/content/307/2/705
Heme Oxygenase heme-oxygenase.com
Just another WordPress site
